Royal Air Force Typhoon FGR4s have operated alongside French warplanes in a coordinated attack on an hidden munitions depot in Syria operated by the Daesh militant organization, according to the UK's MoD.
The location, pinpointed through reconnaissance, was thought to be storing arms and explosives, the release indicated, and was positioned in mountains just north of Palmyra in central Syria.
"The RAF jets employed precision-guided Paveway IV munitions to strike a several access tunnels providing entry to the site... initial indications indicate the objective was successfully hit," the MoD said.
There was no sign of any civilian impact in the operation late on Saturday and each participating jet made a safe return, the ministry further stated.
The British jets were backed up by a Voyager refuelling tanker.
IS - referred to as the so-called Islamic State - enforced extremist governance over large swathes of both Syria and Iraq until 2019.
"This operation underscores the UK's leading role, and determination to stand shoulder to shoulder with allied nations, to eliminate any resurgence of IS and their violent and radical beliefs in the Middle East," Britain's Defence Chief John Healey remarked.
RAF aircraft have carried out overwatch operations over Syria to "forestall any efforts to regroup" of IS after its defeat at the climactic battle in Baghuz in the year 2019, the ministry said.
"I must thank all the members of the UK armed forces who took part in this mission for their professionalism and their bravery," he said. "They were among a great many British personnel on duty over the holidays. This operation, to eliminate dangerous terrorists who pose a risk to our way of life, demonstrates how our armed forces are prepared to act, throughout the year, ensuring Britain's security domestically and strong abroad."
Last December, the American forces carried out what it called a "massive strike" against Daesh sites in the country, subsequent to an ambush resulted in the deaths of two US troops and a civilian linguist in the Palmyra area.
The United Nations reports IS still has between 5,000 and 7,000 combatants in Iraq and Syria.